Transcriptional coregulator Ess2 controls survival of post-thymic CD4⁺ T cells through the Myc and IL-7 signaling pathways.

ABSTRACT: Ess2, also known as Dgcr14, is a transcriptional co-regulator of CD4⁺ T cells. Ess2 is located in a chromosomal region, the loss of which has been associated with 22q11.2 deletion syndrome (22q11DS), which causes heart defects, skeletal abnormalities, and immunodeficiency. However, the specific association of Ess2 with 22q11DS remains unclear. To elucidate the role of Ess2 in T-cell development, we generated Ess2 floxed (Ess2^fl/fl) and CD4⁺ T cell-specific Ess2 KO (Ess2^ΔCD4/ΔCD4) mice using the Cre/loxP system. Interestingly, Ess2^ΔCD4/ΔCD4 mice exhibited reduced naïve T-cell numbers in the spleen, while the number of thymocytes (CD4^-CD8^-, CD4⁺CD8⁺, CD4⁺CD8^-, and CD4

SUBMITTER: Takada I 

PROVIDER: S-EPMC9436822 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature