From target analysis to suspect and non-target screening of endocrine-disrupting compounds in human urine.

ABSTRACT: In the present work, a target analysis method for simultaneously determining 24 diverse endocrine-disrupting compounds (EDCs) in urine (benzophenones, bisphenols, parabens, phthalates and antibacterials) was developed. The target analysis approach (including enzymatic hydrolysis, clean-up by solid-phase extraction and analysis by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS)) was optimized, validated and applied to volunteers' samples, in which 67% of the target EDCs were quantified. For instance, benzophenone-3 (0.2-13 ng g^-1), bisphenol A (7.7-13.7 ng g^-1), methyl 3,5-dihydroxybenzoate (8-254 ng g^-1), mono butyl phthalate (2-17 ng g^-1) and triclosan (0.3-9 ng g^-1) were found at the highest concentrations, but t

SUBMITTER: Musatadi M 

PROVIDER: S-EPMC9436830 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature