Risk of fractures in individuals with eosinophilic esophagitis: nationwide population-based cohort study.

ABSTRACT:

Background and aims

Eosinophilic esophagitis (EoE) is an emerging, chronic immune-mediated disease for which swallowed topical steroids and proton pump inhibitors (PPIs) represent first-line treatments. Immune-mediated diseases, steroids, and PPI use have been linked to osteoporosis. We assessed the risk of fractures in patients with EoE and determined whether the most commonly used treatments for EoE were associated with increased fracture risk.

Methods

We followed a nationwide cohort of 1263 individuals in Sweden with biopsy-verified EoE diagnosed between 2005 and 2016 for first-time fracture of any type. Age- and sex-matched reference individuals were retrieved from the Total Population Register (n = 5164). We estimated hazard ratios (HRs) for fracture in relation to EoE

SUBMITTER: Garber JJ 

PROVIDER: S-EPMC9436880 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature