Brown adipose tissue dysfunction promotes heart failure via a trimethylamine N-oxide-dependent mechanism.

ABSTRACT: Low body temperature predicts a poor outcome in patients with heart failure, but the underlying pathological mechanisms and implications are largely unknown. Brown adipose tissue (BAT) was initially characterised as a thermogenic organ, and recent studies have suggested it plays a crucial role in maintaining systemic metabolic health. While these reports suggest a potential link between BAT and heart failure, the potential role of BAT dysfunction in heart failure has not been investigated. Here, we demonstrate that alteration of BAT function contributes to development of heart failure through disorientation in choline metabolism. Thoracic aortic constriction (TAC) or myocardial infarction (MI) reduced the thermogenic capacity of BAT in mice, leading to significant reduction of body tempera

SUBMITTER: Yoshida Y 

PROVIDER: S-EPMC9436957 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature