High-fat diet causes mechanical allodynia in the absence of injury or diabetic pathology.

ABSTRACT: Understanding the interactions between diet, obesity, and diabetes is important to tease out mechanisms in painful pathology. Western diet is rich in fats, producing high amounts of circulating bioactive metabolites. However, no research has assessed how a high-fat diet (HFD) alone may sensitize an individual to non-painful stimuli in the absence of obesity or diabetic pathology. To investigate this, we tested the ability of a HFD to stimulate diet-induced hyperalgesic priming, or diet sensitization in male and female mice. Our results revealed that 8 weeks of HFD did not alter baseline pain sensitivity, but both male and female HFD-fed animals exhibited robust mechanical allodynia when exposed to a subthreshold dose of intraplantar Prostaglandin E₂ (PGE₂) compared to

SUBMITTER: Tierney JA 

PROVIDER: S-EPMC9437006 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature