Pla2g2a promotes innate Th2-type immunity lymphocytes to increase B1a cells.

ABSTRACT: Newborns require early generation of effective innate immunity as a primary physiological mechanism for survival. The neonatal Lin28⁺Let7^- developmental pathway allows increased generation of Th2-type cells and B1a (B-1 B) cells compared to adult cells and long-term maintenance of these initially generated innate cells. For initial B1a cell growth from the neonatal to adult stage, Th2-type IL-5 production from ILC2s and NKT2 cells is important to increase B1a cells. The Th17 increase is dependent on extracellular bacteria, and increased bacteria leads to lower Th2-type generation. Secreted group IIA-phospholipase A2 (sPLA2-IIA) from the Pla2g2a gene can bind to gram-positive bacteria and degrade bacterial membranes, controlling microbiota in the intestine. BALB/c mice

SUBMITTER: Shinton SA 

PROVIDER: S-EPMC9437038 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature