A compendium of 32,277 metagenome-assembled genomes and over 80 million genes from the early-life human gut microbiome.

ABSTRACT: Age-specific reference genomes of the human gut microbiome can provide higher resolution for metagenomic analyses including taxonomic classification, strain-level genomic investigation and functional characterization. We present the Early-Life Gut Genomes (ELGG) catalog with 32,277 genomes representing 2172 species from 6122 fecal metagenomes collected from children under 3 years old spanning delivery mode, gestational age, feeding pattern, and geography. The ELGG substantially expanded the phylogenetic diversity by 38% over the isolate microbial genomes, and the genomic landscape of the early-life microbiome by increasing recruitment of metagenomic reads to 82.8%. More than 60% of the ELGG species lack an isolate representative. The conspecific genomes of the most abundant species from ch

SUBMITTER: Zeng S 

PROVIDER: S-EPMC9437082 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature