Mendelian randomization study of the effect of coronary artery calcification on atherosclerotic cardiovascular diseases.

ABSTRACT: Calcium calcification in the wall of arteries (CAC) leads to a higher risk of atherosclerosis related outcomes, especially myocardial infarction (MI). Nevertheless, the causal role of CAC on other related outcomes is unclear. In this study, we used Mendelian randomization (MR) to systematically investigate the causal role of CAC across a broad range of atherosclerotic cardiovascular diseases including coronary heart disease, angina, MI, ischemic heart disease, stroke, and peripheral vascular disease. Publicly available data from the UK biobank and other data sources were used. Using the two-sample Mendelian randomization (MR) approach, we applied 3 MR models including the inverse variance weighted, the weighted-median, and the weighted-mode methods. Eight SNPs associated with CAC were sele

SUBMITTER: Sae-Jie W 

PROVIDER: S-EPMC9437097 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature