Altered resting-state functional connectivity of the anterior cingulate cortex in rats post noise exposure.

ABSTRACT:

Aims

We aimed to find where and how noise-induced cochlear hearing loss affects the central nervous system during the early state and identify the neural substrate for aberrant patterns that mediating noise-related anxiety-/depression- like behaviors.

Methods

Broad band noise with 122 dB for 2 hours was conducted to induce hearing loss. We defined 0 day (N0D) and 10 days (N10D) post noise as the acute and sub-acute period. Behavioral tests (Open field test and light/dark test) and resting-state fMRI were computed to evaluate emotional conditions and aberrant neural activity. Functional connectivity analysis using the anterior cingulate cortex as a seed was computed to reveal the spatial distribution beyond auditory network during both periods.

Results

Anxiety-/depress

SUBMITTER: Xu XM 

PROVIDER: S-EPMC9437238 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature