Determination of significant parameters in remote ischemic postconditioning for ischemic stroke in experimental models: A systematic review and meta-analysis study.

ABSTRACT:

Objectives

To systematically review studies using remote ischemia postconditioning (RIPostC) for ischemic stroke in experimental models and obtain factors that significantly influence treatment outcomes.

Materials and methods

Peer-reviewed studies were identified and selected based on the eligibility criteria, followed by extraction of data on potentially influential factors related to model preparation, postconditioning, and measure time based on outcome measures including infarct size, neurological scales, and cell tests with autophagy, apoptosis, normal-neuron, and damaged-neuron counting. Then, all data were preprocessed, grouped, and meta-analyzed with the indicator of the standardized mean difference.

Results

Fifty-seven studies with 224 experiments (91 for infa

SUBMITTER: Liu K 

PROVIDER: S-EPMC9437239 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature