Increased histone citrullination in juvenile idiopathic arthritis.

ABSTRACT:

Objective

Posttranslational modifications (PTMs) of proteins are crucial for regulating various biological processes. However, protein alteration via PTMs, and consequently, the creation of new epitopes, can induce abnormal autoimmune responses in predisposed individuals. Immunopathogenesis of several rheumatic diseases, including the most common childhood form, juvenile idiopathic arthritis (JIA), is associated with the generation of autoantibodies against such modified proteins. Dysregulated generation of neutrophil extracellular traps (NETs) can be a source of post-translationally altered proteins. Thus, we investigated the role of PTMs and the presence of NET-associated markers in JIA patients.

Methods

We recruited 30 pediatric patients with JIA (20 with active di

SUBMITTER: Parackova Z 

PROVIDER: S-EPMC9437311 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature