Lyophilized platelets inhibit platelet aggregation with simultaneous paradoxical promotion of platelet adhesion.

ABSTRACT: Lyophilized platelets have been explored as a potential hemostatic agent due to their long-term ambient storage capabilities that make them readily available in various scenarios. Additionally, their high biocompatibility and the key role of platelet interactions in various clinical conditions make them a promising platform for drug delivery. To explore these applications and for wider clinical deployment, the interactions between lyophilized platelets and fresh platelets must be examined. This project characterized receptor expression on the lyophilized platelet surface and their ability to bind fibrinogen using flow cytometry. The effect of lyophilized platelets on aggregation of unaltered platelets was assessed using light transmission aggregometry while the effect on adhesion was evalu

SUBMITTER: Schnoor B 

PROVIDER: S-EPMC9437314 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature