Changes in intestinal microflora and its metabolites underlie the cognitive impairment in preterm rats.

ABSTRACT:

Background

The brain development of preterm infants is easily affected by various adverse extrauterine factors and complications, resulting in abnormal neurological and cognitive development. Recent studies have found that there is a significant correlation between intestinal microbial changes and cognitive behavior. Nevertheless, the correlation between the cognitive impairment and abnormal changes of intestinal microflora in the preterm newborn has been rarely elucidated.

Aim

To analyze the differences of fecal intestinal flora, short chain fatty acids (SCFAs) and microbiota-gut-brain axis (MGBA)-related serum factors between preterm birth with and without cognitive impairment.

Methods

Healthy female rats (body weight 410 ± 40 g) of 16-17 days of gestation were sele

SUBMITTER: Lu X 

PROVIDER: S-EPMC9437323 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature