Endocrine disrupting chemicals interfere with decidualization of human primary endometrial stromal cells in vitro.

ABSTRACT: Multiple studies have shown associations between exposure to endocrine disrupting chemicals (EDCs) and reduced fertility in women. However, little is known about the target organs of chemical disruption of female fertility. Here, we focus on the hormone-sensitive uterine lining, the endometrium, as a potential target. Decidualization is the morphological and functional change that endometrial stromal cells undergo to support endometrial receptivity, which is crucial for successful implantation, placentation, and pregnancy. We investigated the effect of nine selected EDCs on primary human endometrial stromal cell decidualization in vitro. The cells were exposed to a decidualization-inducing mixture in the presence or absence of 1 μM of nine different EDCs for nine days. Extent of dec

SUBMITTER: Lavogina D 

PROVIDER: S-EPMC9437351 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature