Molecular subtypes of osteosarcoma classified by cancer stem cell related genes define immunological cell infiltration and patient survival.

ABSTRACT: Recent studies have shown that tumor stemness has biological significance in tumorigenicity and tumor progression. However, the characteristics of TME immune infiltration in osteosarcoma mediated by the combined effects of multiple cancer stem cell-related genes remain unknown.

Methods

In this study, we identified different cancer stem cell-associated subtypes in osteosarcoma based on 25 cancer stem cell-associated genes by consensus clustering analysis, and we comprehensively evaluated the association between these subtypes and immunocytes infiltration in the TME. The cancer stem cell (CSC) score was constructed to quantify the stemness of individual tumors.

Results

We performed a comprehensive evaluation of 218 osteosarcoma patients based on 25 cancer stem cell-related gene

SUBMITTER: Guo L 

PROVIDER: S-EPMC9437352 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature