Frailty and risks of all-cause and cause-specific death in community-dwelling adults: a systematic review and meta-analysis.

ABSTRACT:

Background

The associations of frailty with all-cause and cause-specific mortality remain unclear. Therefore, we performed this meta-analysis to fill this gap.

Methods

We searched the PubMed and Embase databases through June 2022. Prospective cohort studies or clinical trials examining frailty were evaluated, and the multiple adjusted risk estimates of all-cause and cause-specific mortality, such as death from cardiovascular disease (CVD), cancer, respiratory illness, dementia, infection, and coronavirus disease 2019 (COVID-19), were included. A random effects model was used to calculate the summary hazard ratio (HR).

Results

Fifty-eight studies were included for the qualitative systematic review, of which fifty-six studies were eligible for the quantitative meta-anal

SUBMITTER: Peng Y 

PROVIDER: S-EPMC9437382 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature