Vitamin K antagonists and cardiovascular calcification: A systematic review and meta-analysis.

ABSTRACT:

Background

Many patients treated with Vitamin K antagonists (VKA) for anticoagulation have concomitant vascular or valvular calcification. This meta-analysis aimed to evaluate a hypothesis that vascular and valvular calcification is a side-effect of VKA treatment.

Methods

We conducted a systematic literature search to identify studies that reported vascular or valvular calcification in patients treated with VKA. The associations between VKA use and calcification were analyzed with random-effects inverse variance models and reported as odds ratios (OR) and 95% confidence intervals (95% CI). In addition, univariate meta-regression analyses were utilized to identify any effect moderators.

Results

Thirty-five studies were included (45,757 patients; 6,251 VKA users). The m

SUBMITTER: Kosciuszek ND 

PROVIDER: S-EPMC9437425 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature