Aberrant activation of KRAS in mouse theca-interstitial cells results in female infertility.

ABSTRACT: KRAS plays critical roles in regulating a range of normal cellular events as well as pathological processes in many tissues mediated through a variety of signaling pathways, including ERK1/2 and AKT signaling, in a cell-, context- and development-dependent manner. The in vivo function of KRAS and its downstream targets in gonadal steroidogenic cells for the development and homeostasis of reproductive functions remain to be determined. To understand the functions of KRAS signaling in gonadal theca and interstitial cells, we generated a Kras mutant (tKrasMT) mouse line that selectively expressed a constitutively active Kras ^G12D in these cells. Kras ^G12D expression in ovarian theca cells did not block follicle development

SUBMITTER: Sun P 

PROVIDER: S-EPMC9437434 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature