Seizure control does not predict hippocampal subfield volume change in children with focal drug-resistant epilepsy.

ABSTRACT:

Background and purpose

Recurrent seizures have been reported to induce neuronal loss in the hippocampus. It is unclear whether seizure control influences hippocampal volume. The aims of this study were to determine if there was a change in total or subfield hippocampal volume over time in children with focal drug-resistant epilepsy, and whether seizure control influenced total or subfield hippocampal volumes.

Methods

Using FreeSurfer's automated segmentation of brain magnetic resonance imaging scans, we calculated the total and subfield (including CA1, CA3, CA4, subiculum, presubiculum, parasubiculum, molecular layer and dentate gyrus) hippocampal volumes of children with non-lesional focal epilepsy. Seizure frequency and hippocampal volumes were assessed at baseline and fol

SUBMITTER: Wagner MW 

PROVIDER: S-EPMC9437498 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature