Metabolic profiling reveals new serum signatures to discriminate lupus nephritis from systemic lupus erythematosus.

ABSTRACT:

Background

Lupus nephritis (LN) occurs in 50% of patients with systemic lupus erythematosus (SLE), causing considerable morbidity and even mortality. Previous studies had shown the potential of metabolic profiling in the diagnosis of SLE or LN. However, few metabonomics studies have attempted to distinguish SLE from LN based on metabolic changes. The current study was designed to find new candidate serum signatures that could differentiate LN from SLE patients using a non-targeted metabonomics method based on ultra high performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS).

Method

Metabolic profiling of sera obtained from 21 healthy controls, 52 SLE patients and 43 LN patients. We used SPSS 25.0 for statistical analysis. Principal component analysis (PCA),

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9437530 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature