Association of longitudinal platelet count trajectory with ICU mortality: A multi-cohort study.

ABSTRACT:

Objective

Platelet (PLT) engages in immune and inflammatory responses, all of which are related to the prognosis of critically ill patients. Although thrombocytopenia at ICU admission contributes to in-hospital mortality, PLT is repeatedly measured during ICU hospitalization and the role of longitudinal PLT trajectory remains unclear. We aimed to identify dynamic PLT trajectory patterns and evaluate their relationships with mortality risk and thrombocytopenia.

Methods

We adopted a three-phase, multi-cohort study strategy. Firstly, longitudinal PLT trajectory patterns within the first four ICU days and their associations with 28-day survival were tested in the eICU Collaborative Research Database (eICU-CRD) and independently validated in the Medical Information Mart for Inten

SUBMITTER: Chen J 

PROVIDER: S-EPMC9437551 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature