Incorporating nanocrystalline cellulose into a multifunctional hydrogel for heart valve tissue engineering applications.

ABSTRACT: Functional tissue engineered heart valves (TEHV) have been an elusive goal for nearly 30 years. Among the persistent challenges are the requirements for engineered valve leaflets that possess nonlinear elastic tissue biomechanical properties, support quiescent fibroblast phenotype, and resist osteogenic differentiation. Nanocellulose is an attractive tunable biological material that has not been employed to this application. In this study, we fabricated a series of photocrosslinkable composite hydrogels mNCC-MeGel (mNG) by conjugating TEMPO-modified nanocrystalline cellulose (mNCC) onto the backbone of methacrylated gelatin (MeGel). Their structures were characterized by FTIR, ¹ HNMR and uniaxial compression testing. Human adipose-derived mesenchymal stem cells (HADMSC) were enc

SUBMITTER: Ma N 

PROVIDER: S-EPMC9437634 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature