Does comorbidity burden explain the higher COVID-19 mortality risk among men? A retrospective cross-sectional analysis of a well-defined cohort of patients in Bronx, New York

ABSTRACT:

Objectives

Men have a higher mortality rate and more severe COVID-19 infection than women. The mechanism for this is unclear. We hypothesise that innate sex differences, rather than comorbidity burden, drive higher male mortality.

Design

Retrospective cohort.

Setting

Montefiore Health System (MHS) in Bronx, New York, USA.

Participants

A cohort population of 364 992 patients at MHS between 1 January 2018 and 1 January 2020 was defined, from which individuals hospitalised during the pre-COVID period (1 January 2020–15 February 2020) (n=5856) and individuals hospitalised during the COVID-19 surge (1 March 2020–15 April 2020) (n=4793) were examined for outcomes. A subcohort with confirmed COVID-19+ hospitalisation was also examined (n=1742).

Primary and

SUBMITTER: Vasa A 

PROVIDER: S-EPMC9437736 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature