Health-related quality of life trajectory of treatment-naive patients with Merkel cell carcinoma receiving avelumab.
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ABSTRACT:
SUBMITTER: Bharmal M
PROVIDER: S-EPMC9437770 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Publications
Health-related quality of life trajectory of treatment-naive patients with Merkel cell carcinoma receiving avelumab.
Bharmal Murtuza M Nolte Sandra S Lebbé Céleste C Mortier Laurent L Brohl Andrew S AS Fazio Nicola N Grob Jean-Jacquez JJ Pusceddu Sara S Hanna Glenn J GJ Hassel Jessica C JC Kiecker Felix F Ellers-Lenz Barbara B Bajars Marcis M Güzel Gülseren G Nghiem Paul P Hunger Matthias M Schlichting Michael M Henry-Szatkowski Mickaël M D'Angelo Sandra P SP
Future oncology (London, England) 20200917 27
<b>Aim:</b> To evaluate changes in health-related quality of life (HRQoL) in a Phase II trial (NCT02155647) of treatment-naive patients with metastatic Merkel cell carcinoma treated with avelumab (15-month follow-up). <b>Materials & methods:</b> Mixed-effect Models for Repeated Measures were applied to HRQoL data (FACT-M; EQ-5D-5L) to assess changes over time. Clinically derived progression-free survival was compared with HRQoL deterioration-free survival. <b>Results:</b> Overall, we saw relativ ...[more]
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