Ontology highlight
ABSTRACT:
SUBMITTER: Viker KB
PROVIDER: S-EPMC9437807 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Viker Kimberly B KB Steele Michael B MB Iankov Ianko D ID Concilio Susanna C SC Ammayappan Arun A Bolon Brad B Jenks Nathan J NJ Goetz Matthew P MP Panagioti Eleni E Federspiel Mark J MJ Liu Minetta C MC Peng Kah Whye KW Galanis Evanthia E
Molecular therapy. Methods & clinical development 20220731
Despite recent therapeutic advances, metastatic breast cancer (MBC) remains incurable. Engineered measles virus (MV) constructs based on the attenuated MV Edmonston vaccine platform have demonstrated significant oncolytic activity against solid tumors. The <i>Helicobacter pylori</i> neutrophil-activating protein (NAP) is responsible for the robust inflammatory reaction in gastroduodenal mucosa during bacterial infection. NAP attracts and activates immune cells at the site of infection, inducing ...[more]