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Rapid, enantioselective and colorimetric detection of D-arginine.

ABSTRACT: D-amino acids are of biological significance yet are not clearly understood due to the lack of powerful analytical tools for their identification. Thus, the specific detection of a single enantiomer of a particular amino acid remains a great challenge due to their structural similarity. Here, we report a strategy to incorporate multiple reaction sites on a chiral 1,1'-bi-2,2'-naphthol-based fluorescent probe. It can respond specifically to D-arginine, while producing no response when in contact with all other amino acids. The probe can report arginine's concentration, and enantiomeric configuration and colorimetric studies enable its qualitative determination.

SUBMITTER: Yu X

PROVIDER: S-EPMC9437853 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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Rapid, enantioselective and colorimetric detection of D-arginine.

Yu Xianzhe X Zhang Binjie B Fan Cailing C Yan Qianqian Q Wang Shenglin S Hu Hui H Dong Qinxi Q Du Gengyu G Gao Yanan Y Zeng Chaoyuan C

iScience 20220817 9

D-amino acids are of biological significance yet are not clearly understood due to the lack of powerful analytical tools for their identification. Thus, the specific detection of a single enantiomer of a particular amino acid remains a great challenge due to their structural similarity. Here, we report a strategy to incorporate multiple reaction sites on a chiral 1,1'-bi-2,2'-naphthol-based fluorescent probe. It can respond specifically to D-arginine, while producing no response when in contact ...[more]

PMID: 36060051

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