Dynamics of hepatocyte-cholangiocyte cell-fate decisions during liver development and regeneration.

ABSTRACT: The immense regenerative potential of the liver is attributed to the ability of its two key cell types - hepatocytes and cholangiocytes - to trans-differentiate to one another either directly or through intermediate progenitor states. However, the dynamic features of decision-making between these cell-fates during liver development and regeneration remains elusive. Here, we identify a core gene regulatory network comprising c/EBPα, TGFBR2, and SOX9 which is multistable in nature, enabling three distinct cell states - hepatocytes, cholangiocytes, and liver progenitor cells (hepatoblasts/oval cells) - and stochastic switching among them. Predicted expression signature for these three states are validated through multiple bulk and single-cell transcriptomic datasets collected across de

SUBMITTER: Sahoo S 

PROVIDER: S-EPMC9437857 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature