Covalent Organic Framework Based on Azacalix[4]arene for the Efficient Capture of Dialysis Waste Products.

ABSTRACT: Azacalix[n]arenes (ACAs) are lesser-known cousins of calix[n]arenes that contain amine bridges instead of methylene bridges, so they generally have higher flexibility due to enlarged cavities. Herein, we report a highly substituted cationic azacalix[4]arene-based covalent organic framework (ACA-COF) synthesized by the Zincke reaction under microwave irradiation. The current work is a rare example of a synthetic strategy that utilizes the chemical functionalization of an organic macrocycle to constrain its conformational flexibility and, thereby, produce an ordered material. Considering the ACA cavity dimensions, and the density and diversity of the polar groups in ACA-COF, we used it for adsorption of uric acid and creatinine, two major waste products generated

SUBMITTER: Skorjanc T 

PROVIDER: S-EPMC9437870 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature