Pyroptosis-related gene-based prognostic signature for predicting the overall survival of oral squamous cell carcinoma patients.

ABSTRACT:

Purpose

Oral squamous cell carcinoma (OSCC) is the most common oral cancer worldwide. Pyroptosis is a type of programmed cell death mediated by caspase, accompanied by an inflammatory response, and plays an important role in cancer progression. The purpose of this study was to explore and identify potential biomarkers and further elucidate the potential role of cell pyroptosis in OSCC.

Methods

We regarded the samples from The Cancer Genome Atlas database as a training dataset, screened differentially expressed genes (DEGs), and further screened out OSCC phenotypic characteristic genes by using weighted gene co-expression network analysis. The analysis of 42 known pyroptosis-related genes showed that Psuch genes were widely expressed, mutated, and methylated in OSCC samples.<

SUBMITTER: Zeng D 

PROVIDER: S-EPMC9437919 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature