Ontology highlight
ABSTRACT:
SUBMITTER: Zhao F
PROVIDER: S-EPMC9437973 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Zhao Fabao F Atxabal Unai U Mariottini Sofia S Yi Feng F Lotti James S JS Rouzbeh Nirvan N Liu Na N Bunch Lennart L Hansen Kasper B KB Clausen Rasmus P RP
Journal of medicinal chemistry 20211217 1
NMDA receptors mediate glutamatergic neurotransmission and are therapeutic targets due to their involvement in a variety of psychiatric and neurological disorders. Here, we describe the design and synthesis of a series of (<i>R</i>)-3-(5-furanyl)carboxamido-2-aminopropanoic acid analogues <b>8a</b>-<b>s</b> as agonists at the glycine (Gly) binding site in the GluN1 subunit, but not GluN3 subunits, of NMDA receptors. These novel analogues display highly variable potencies and agonist efficacies a ...[more]