Arginine catabolism metabolites and atrial fibrillation or heart failure risk: 2 case-control studies within the Prevencion con Dieta Mediterranea (PREDIMED) trial.

ABSTRACT:

Background

Arginine-derived metabolites are involved in oxidative and inflammatory processes related to endothelial functions and cardiovascular risks.

Objectives

We prospectively examined the associations of arginine catabolism metabolites with the risks of atrial fibrillation (AF) or heart failure (HF), and evaluated the potential modifications of these associations through Mediterranean diet (MedDiet) interventions in a large, primary-prevention trial.

Methods

Two nested, matched, case-control studies were designed within the Prevención con Dieta Mediterránea (PREDIMED) trial. We selected 509 incident cases and 547 matched controls for the AF case-control study and 326 cases and 402 matched controls for the HF case-control study using incidence density sampling. Fa

SUBMITTER: Goni L 

PROVIDER: S-EPMC9437981 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature