A single, high-fat meal adversely affects postprandial endothelial function: a systematic review and meta-analysis.

ABSTRACT:

Background

Endothelial dysfunction is a predictive risk factor for the development of atherosclerosis and is assessed by flow-mediated dilation (FMD). Although it is known that NO-dependent endothelial dysfunction occurs after consuming a high-fat meal, the magnitude of the effect and the factors that affect the response are unquantified.

Objectives

We conducted a systematic review and meta-analysis exploring the quantitative effects of a single high-fat meal on endothelial function and determined the factors that modify the FMD response.

Methods

Six databases were systematically searched for original research published up to January 2022. Eligible studies measured fasting and postprandial FMD following consumption of a high-fat meal. Meta-regression was used to analy

SUBMITTER: Fewkes JJ 

PROVIDER: S-EPMC9437993 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature