Assessment of the effects of dexmedetomidine on outcomes of traumatic brain injury using propensity score analysis.

ABSTRACT:

Background

Dexmedetomidine was found to be protective against traumatic brain injury (TBI) in animal studies and safe for use in previous clinical studies, but whether it improves TBI patient survival remains to be determined. We sought to answer this question by analyzing data from the MIMIC clinical database.

Methods

Data for TBI patients from the MIMIC III and MIMIC IV databases were extracted and divided into a dexmedetomidine group and a control group. In the former group, dexmedetomidine was used for sedation, while in the latter, it was not used. Parameters including patient age, the Acute Physiology score III, the Glasgow Coma Scale, other sedatives used, and pupillary response within 24 h were employed in propensity score matching to achieve a balance between groups

SUBMITTER: Xu J 

PROVIDER: S-EPMC9438148 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature