Cardiovascular risk of gabapentin and pregabalin in patients with diabetic neuropathy.

ABSTRACT:

Background

Gabapentin and pregabalin are commonly prescribed medications to treat pain in patients with diabetic neuropathy. Gabapentin and pregabalin can cause fluid retention, which is hypothesized to be associated with cardiovascular diseases. However, whether long-term use of gabapentin and pregabalin is associated with adverse cardiovascular diseases remains unknown. This study aims to examine the association between gabapentin use, pregabalin use and several adverse cardiovascular events.

Methods

This retrospective cohort study used propensity score matching within patient electronic health records (EHRs) from a multicenter database with 106 million patients from 69 health care organizations in the US. The study population comprised 210,064 patients who had a diagnosis

SUBMITTER: Pan Y 

PROVIDER: S-EPMC9438165 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature