Dynamic network model reveals distinct tau spreading patterns in early- and late-onset Alzheimer disease.

ABSTRACT:

Background

The clinical features of Alzheimer's disease (AD) vary substantially depending on whether the onset of cognitive deficits is early or late. The amount and distribution patterns of tau pathology are thought to play a key role in the clinical characteristics of AD, which spreads throughout the large-scale brain network. Here, we describe the differences between tau-spreading processes in early- and late-onset symptomatic individuals on the AD spectrum.

Methods

We divided 74 cognitively unimpaired (CU) and 68 cognitively impaired (CI) patients receiving ¹⁸F-flortaucipir positron emission tomography scans into two groups by age and age at onset. Members of each group were arranged in a pseudo-longitudinal order based on baseline tau pathology severity, and

SUBMITTER: Lee WJ 

PROVIDER: S-EPMC9438183 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature