LRP1 is a neuronal receptor for α-synuclein uptake and spread.

ABSTRACT:

Background

The aggregation and spread of α-synuclein (α-Syn) protein and related neuronal toxicity are the key pathological features of Parkinson's disease (PD) and Lewy body dementia (LBD). Studies have shown that pathological species of α-Syn and tau can spread in a prion-like manner between neurons, although these two proteins have distinct pathological roles and contribute to different neurodegenerative diseases. It is reported that the low-density lipoprotein receptor-related protein 1 (LRP1) regulates the spread of tau proteins; however, the molecular regulatory mechanisms of α-Syn uptake and spread, and whether it is also regulated by LRP1, remain poorly understood.

Methods

We established LRP1 knockout (LRP1-KO) human induced pluripotent stem cells (iPSCs) isogenic li

SUBMITTER: Chen K 

PROVIDER: S-EPMC9438229 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature