Development and validation of the MMCD score to predict kidney replacement therapy in COVID-19 patients.

ABSTRACT:

Background

Acute kidney injury (AKI) is frequently associated with COVID-19, and the need for kidney replacement therapy (KRT) is considered an indicator of disease severity. This study aimed to develop a prognostic score for predicting the need for KRT in hospitalised COVID-19 patients, and to assess the incidence of AKI and KRT requirement.

Methods

This study is part of a multicentre cohort, the Brazilian COVID-19 Registry. A total of 5212 adult COVID-19 patients were included between March/2020 and September/2020. Variable selection was performed using generalised additive models (GAM), and least absolute shrinkage and selection operator (LASSO) regression was used for score derivation. Accuracy was assessed using the area under the receiver operating characteristic curve

SUBMITTER: Figueiredo FA 

PROVIDER: S-EPMC9438299 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature