Challenges and perspectives of tendon-derived cell therapy for tendinopathy: from bench to bedside.

ABSTRACT: Tendon is composed of dense fibrous connective tissues, connecting muscle at the myotendinous junction (MTJ) to bone at the enthesis and allowing mechanical force to transmit from muscle to bone. Tendon diseases occur at different zones of the tendon, including enthesis, MTJ and midsubstance of the tendon, due to a variety of environmental and genetic factors which consequently result in different frequencies and recovery rates. Self-healing properties of tendons are limited, and cell therapeutic approaches in which injured tendon tissues are renewed by cell replenishment are highly sought after. Homologous use of individual's tendon-derived cells, predominantly differentiated tenocytes and tendon-derived stem cells, is emerging as a treatment for tendinopathy through achieving minimal cel

SUBMITTER: Chen Z 

PROVIDER: S-EPMC9438319 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature