Multiple-site decontamination regimen decreases acquired infection incidence in mechanically ventilated COVID-19 patients.

ABSTRACT:

Background

Among strategies that aimed to prevent acquired infections (AIs), selective decontamination regimens have been poorly studied in the COVID-19 setting. We assessed the impact of a multiple-site decontamination (MSD) regimen on the incidence of bloodstream infections (BSI) and ventilator-associated pneumonia (VAP) in COVID-19 patients receiving mechanical ventilation.

Methods

We performed an ancillary analysis of a multicenter retrospective observational study in 15 ICUs in western France. In addition to standard-care (SC), 3 ICUs used MSD, a variant of selective digestive decontamination, which consists of the administration of topical antibiotics four times daily in the oropharynx and the gastric tube, chlorhexidine body wash and a 5-day nasal mupirocin course. AI

SUBMITTER: Massart N 

PROVIDER: S-EPMC9438389 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature