Classic and Novel Mechanisms of Diuretic Resistance in Cardiorenal Syndrome.

ABSTRACT: Despite the incompletely understood multiple etiologies and underlying mechanisms, cardiorenal syndrome is characterized by decreased glomerular filtration and sodium avidity. The underlying level of renal sodium avidity is of primary importance in driving a congested heart failure phenotype and ultimately determining the response to diuretic therapy. Historically, mechanisms of kidney sodium avidity and resultant diuretic resistance were primarily extrapolated to cardiorenal syndrome from non-heart failure populations. Yet, the mechanisms appear to differ between these populations. Recent literature in acute decompensated heart failure has refuted several classically accepted diuretic resistance mechanisms and reshaped how we conceptualize diuretic resistance mechanisms in cardiorenal syn

SUBMITTER: Cox ZL 

PROVIDER: S-EPMC9438407 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature