F4/80^hi Resident Macrophages Contribute to Cisplatin-Induced Renal Fibrosis.

ABSTRACT:

Background

Cisplatin-induced kidney injury remains a major obstacle in utilizing cisplatin as a chemotherapeutic for solid-organ cancers. Thirty percent of patients treated with cisplatin develop acute kidney injury (AKI), and even patients who do not develop AKI are at risk for long-term declines in kidney function and development of chronic kidney disease (CKD). Modeling cisplatin-induced kidney injury in mice has revealed that repeated low doses of cisplatin lead to development of kidney fibrosis. This model can be used to examine AKI-to-CKD transition processes. Macrophages play a role in some of these processes, including immune response, wound healing, and tissue remodeling. Depleting macrophage populations in the kidney reduced fibrosis development in other models of renal f

SUBMITTER: Sears SM 

PROVIDER: S-EPMC9438415 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature