Iron Supplementation Improves Skeletal Muscle Contractile Properties in Mice with CKD.

ABSTRACT:

Background

Patients with chronic kidney disease (CKD) frequently have compromised physical performance, which increases their mortality; however, their skeletal muscle dysfunction has not been characterized at the single-fiber and molecular levels. Notably, interventions to mitigate CKD myopathy are scarce.

Methods

The effect of CKD in the absence and presence of iron supplementation on the contractile function of individual skeletal muscle fibers from the soleus and extensor digitorum longus muscles was evaluated in 16-week-old mice. CKD was induced by the adenine diet, and iron supplementation was by weekly iron dextran injections.

Results

Maximally activated and fatigued fiber force production was decreased 24%-52% in untreated CKD, independent of size, by reducing

SUBMITTER: Momb BA 

PROVIDER: S-EPMC9438424 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature