Synthesis and antibacterial activity studies in vitro of indirubin-3'-monoximes.

ABSTRACT: Multi-drug-resistant microbial pathogens are a serious global health problem. New compounds with antibacterial activity serve as good candidates for developing novel antibacterial drugs which is very urgent and important. In this work, based on the unique scaffold of indirubin, an active ingredient of traditional Chinese medicine formulation Danggui Luhui Wan, we synthesized 29 indirubin-3'-monoximes and preliminarily evaluated their antibacterial activities. The antibacterial activity results demonstrated that the synthesized indirubin-3'-monoximes 5a-5z and 5aa-5ad displayed good potency against S. aureus ATCC25923 (MIC = 0.4-25.6 μg mL^-1). Among them, we found that the 5-F, 5-Cl and 7-CF₃ substituted indirubin-3'-monoximes 5r, 5s and 5aa also showed better a

SUBMITTER: Yang FF 

PROVIDER: S-EPMC9438470 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature