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Changes in immunological parameters by ageing in rural healthy Indian adults and their associations with sex and lifestyle.

ABSTRACT: Several factors including sex and lifestyle have been reported to contribute to the age-related alteration of immune functions. The study was undertaken to determine age-related differences in the proportion of peripheral blood mononuclear lymphocytes in the Indian population using blood samples from 67 healthy adults (33 females and 34 males) aged between 20 and 80 years old. In the linear regression analysis to estimate the relationship with age categories, there was a significant increase in the frequency of natural killer cells with ageing, while their cytolytic activity significantly declined. The frequency of CD4⁺ T cells increased with age, whereas that of CD8⁺ T cells decreased, resulting in the age-associated increase of the CD4/CD8 ratio. The subsets of B cells did not show any significant relationship with age. Although there were variations between the male and female subgroups in effect size of ageing, the trends were in the same direction in all the parameters. Reduced fat intake was associated with a lower frequency of CD4⁺ T cells, and higher serum cotinine level was associated with a higher CD4/CD8 ratio. The results indicate that cellular immunity in the Indian population is affected by ageing, while humoral immunity is less susceptible to ageing.

SUBMITTER: Agarwal D

PROVIDER: S-EPMC9438881 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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Changes in immunological parameters by ageing in rural healthy Indian adults and their associations with sex and lifestyle.

Agarwal Dhiraj D Paul Sourav S Lele Pallavi P Piprode Vikrant V Kawade Anand A Hajela Neerja N Bavdekar Ashish A Parulekar Varsha V Ginde Manisha M Paranjape Gandhali G Matsuda Kazunori K Hori Tetsuji T Juvekar Sanjay S Lal Girdhari G

Scientific reports 20220902 1

Several factors including sex and lifestyle have been reported to contribute to the age-related alteration of immune functions. The study was undertaken to determine age-related differences in the proportion of peripheral blood mononuclear lymphocytes in the Indian population using blood samples from 67 healthy adults (33 females and 34 males) aged between 20 and 80 years old. In the linear regression analysis to estimate the relationship with age categories, there was a significant increase in ...[more]

PMID: 36056136

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Project description:AimThis study aimed to assess the impact of a mHealth and community health education intervention on diabetes awareness and promoting healthy dietary and lifestyle habits within a rural population in Andhra Pradesh, India.MethodsUsing a quasi-experimental design, the mDiabetes program was implemented for 1 year, among 1,03,538 rural individuals. Under this program, 56 diabetes prevention messages (twice a week) in local language) were disseminated among the participants via voice calls for a period of 6 months. Additionally, community health education meetings were facilitated by trained community health workers and educational leaflets were distributed among the community members. Questionnaires were administered at three different time points-baseline (before the intervention), endline (after intervention), and follow-up (3 months after endline) to collect demographic data, diabetes-related knowledge, attitudes, practices, physical activity, and dietary habits. Analysis compared data from 545 subjects who participated in all the three surveys.ResultsThe cohort comprised 45.5% males and 54.5% females, aged 19-85 years (mean: 55.42; SD 10.3). Post-intervention, diabetes awareness rose to 97.43% at endline and 99.63% at follow-up from 82.75% at baseline. Belief in diabetes preventability increased from 25.5% to 69.5%, and awareness of lifestyle's impact on diabetes management improved from 72.6% to 80.9%. Over 90% recalled prevention messages, with significant lifestyle changes reported by 83% at endline and 73% at follow-up. Improved dietary and activity habits were evident, with fruit consumption and high-fat food avoidance at 78.5% and 67.7% in follow-up. Physical activity levels improved in both endline and follow-up groups compared to baseline. Daily participation in yoga, running, gym, and aerobics increased to 38.7% in endline and follow-up from 7.3% at baseline (p < 0.001). Outdoor sports engagement rose significantly to 15% in endline and follow-up from 0.5% at baseline (p < 0.001). Regular stair usage (59.8%), walking for chores (84.7%), and short walking breaks (93%) increased significantly in follow-up compared to baseline and endline (p < 0.001).ConclusionThe combined mHealth and community health education intervention improved diabetes awareness and healthy habits in rural areas, showing potential for lasting outcomes and guiding future public health efforts in similar settings.

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Dataset Information

Changes in immunological parameters by ageing in rural healthy Indian adults and their associations with sex and lifestyle.

Publications

Changes in immunological parameters by ageing in rural healthy Indian adults and their associations with sex and lifestyle.

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