Survival Outcomes of Adjuvant Chemotherapy in Elderly Patients with Stage III Colon Cancer.

ABSTRACT:

Background

The survival impact of multi-agent (MAC) compared with single-agent (SAC) adjuvant chemotherapy (AC) in elderly patients with stage III colon cancer (CC) remains controversial. The aim of this study was to compare survival outcomes of MAC and SAC in this population utilizing the National Cancer Database (NCDB).

Patients and methods

Patients aged ≥70 years with pathological stage III CC diagnosed in 2004-2015 were identified in the NCDB. Univariate and multivariable analyses were conducted, and Kaplan-Meier analysis and Cox proportional hazard models were used to identify associations between MAC vs. SAC and overall survival (OS).

Results

Among 41 707 elderly patients (≥70 years old) with stage III CC, about half (n = 20 257; 48.5%) received AC; the majority

SUBMITTER: Khalil L 

PROVIDER: S-EPMC9438921 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature