Connectivity impairment of cerebellar and sensorimotor connector hubs in Parkinson's disease.

ABSTRACT: Cognitive and movement processes involved integration of several large-scale brain networks. Central to these integrative processes are connector hubs, brain regions characterized by strong connections with multiple networks. Growing evidence suggests that many neurodegenerative and psychiatric disorders are associated with connector hub dysfunctions. Using a network metric called functional connectivity overlap ratio, we investigated connector hub alterations in Parkinson's disease. Resting-state functional MRI data from 99 patients (male/female = 44/55) and 99 age- and sex-matched healthy controls (male/female = 39/60) participating in our cross-sectional study were used in the analysis. We have identified two sets of connector hubs, mainly located in the sensorimotor cortex and cerebell

SUBMITTER: Bagarinao E 

PROVIDER: S-EPMC9438962 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature