Developmental patterning of irritability enhances prediction of psychopathology in preadolescence: Improving RDoC with developmental science.

ABSTRACT: The transdiagnostic importance of irritability in psychopathology has been demonstrated. However, the contribution of developmentally unfolding irritability patterns to specific clinical and neural outcomes remains an important and unanswered question. To address this gap in the literature, irritability patterns of 110 youth from a large, diverse cohort were assessed at preschool age and again at early school age (∼2.5 years later) with a dimensional irritability scale designed to capture the normal:abnormal spectrum. At preadolescence (∼6 years later), clinical outcomes (internalizing/externalizing symptoms) derived from a semistructured clinical interview and neural outcomes (characterized as gray-matter-volume abnormalities) were assessed. For clinical outcomes, preschool-age irritabili

SUBMITTER: Damme KSF 

PROVIDER: S-EPMC9439570 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature