A double-blind study assessing the impact of orbitofrontal theta burst stimulation on goal-directed behavior.

ABSTRACT: Patients with disorders of compulsivity show impairments in goal-directed behavior, which have been linked to orbitofrontal cortex (OFC) dysfunction. We recently showed that continuous theta burst stimulation (cTBS), which reduces OFC activity, had a beneficial effect on compulsive behaviors both immediately and at 1 week follow-up compared with inhibitory TBS (iTBS). In this same sample, we investigated whether two behavioral measures of goal-directed control (devaluation success on a habit override task; model-based planning on the two-step task) were also affected by acute modulation of OFC activity. Overall, model-based planning and devaluation success were significantly related to each other and (for devaluation success) to symptoms in our transdiagnostic clinical sample. These measur

SUBMITTER: Brown VM 

PROVIDER: S-EPMC9439586 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature