Suppressed serological vitamin A in patients with liver cirrhosis is associated with impaired liver function and clinical detoriation.

ABSTRACT:

Background

The liver is of critical importance for the homeostasis of metabolic and immunomodulatory properties as well as the storage of vitamins, especially vitamin A. In this prospective analysis, the incidence of serological vitamin A deficiency and the association with disease severity as well as clinical complications in patients with liver cirrhosis were investigated.

Method

From May 2017 to May 2018, 159 patients with primarily alcohol-associated and non-alcoholic steatohepatitis (NASH)-associated preexisting liver cirrhosis were prospectively enrolled and vitamin A status was collected. Clinical complications and infections were followed and recorded over a period of 1-year follow-up. Selected findings were validated in an independent cohort of 44 patients.

Resul

SUBMITTER: Nagel M 

PROVIDER: S-EPMC9439687 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature