Separation and Characterization of Novel Degradation and Process Related Impurities of Bedaquiline Bulk Drug.

ABSTRACT: Bedaquiline (BDQ) is a new drug approved by United States Food and Drug Administration (USFDA) in 2012 for the treatment of drug-resistant tuberculosis, which has become a major threat globally. The manuscript presents the development of three liquid chromatography (LC) based analytical methods. The first is a stability indicating RP-HPLC (reverse phase-high performance liquid chromatography) method to analyze the BDQ in presence of its degradation products. Another UPLC/ESI-MS (ultra-performance liquid chromatography/electron spray ionization-mass spectrometry) method was developed for the identification of different degradation based and process related impurities and the third, preparative HPLC method was developed for the isolation of major degradation products. Eleven degradation prod

SUBMITTER: Vanavi PJ 

PROVIDER: S-EPMC9439945 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature